Melissa Wilson Sayres is an evolutionary and computational biologist. She uses bioinformatics and genomics to study sex-biased processes including: the evolutionary dynamics of sex chromosomes, male mutation bias, and pregnancy. Her work has shown that more mutations are inherited through the male germline (sperm) than through the female germline (egg) in all mammalian species, and that although the human Y chromosome has shrunk significantly, the content on the Y chromosome is important.